DNA ligases seal five′-PO4 and 3′-OH polynucleotide ends via a few nucleotidyl transfer measures involving ligase-adenylate and DNA-adenylate intermediates. DNA ligases are critical guardians of genomic integrity, and ligase dysfunction underlies human genetic illness syndromes. Crystal structures of DNA ligases sure to nucleotide and nucleic acid substrates have illuminated https://griffinolfas.blogrenanda.com/33908140/the-ufabet-by-ligaz-diaries