There is a launch of norepinephrine through the descending inhibitory bulbospinal neurons that binds to alpha-2-receptors during the dorsal horn to lessen afferent discomfort transmission and make analgesia. As a result, medications like clonidine that target alpha-2 receptors can impact the transmission of agony. Applies to clonidine: oral pill, https://zalmays071bxb5.mysticwiki.com/user