Epidural clonidine applied as an adjunct to local anesthetics has a few distinctive mechanisms of action. Initially, the stimulation of alpha-two-receptors within the dorsal horn reduces agony transmission. Secondly, clonidine could potentially cause nearby vasoconstriction that boundaries vascular removal of nearby epidural anesthetics. Clonidine is distributed in breast milk; https://www.proleviate.com/post/the-new-pain-killer-conolidine