Monitor Closely (1)pentobarbital will decrease the level or effect of buprenorphine subdermal implant by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Monitor patients already on buprenorphine subdermal implant who require newly-initiated treatment with CYP3A4 inducer for signs and symptoms of withdrawal. If the porzione of the concomitant CYP3... https://setbookmarks.com/story20342554/la-guida-definitiva-a-pentobarbital-half-life